Key result
Type 2 diabetes is linked to elevated atherogenic lipids in ~70% of patients versus Type 1.
Why the study?
Changes in lipid profile have been investigated to be associated with diabetes mellitus, motivating a comprehensive analysis of lipid profiles in diabetic patients.
Do lipid profiles differ significantly between patients with Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, and healthy controls?
Case-Control (n=150)
No
Do lipid profiles differ significantly between patients with Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, and healthy controls?
Patients with Type 2 Diabetes Mellitus exhibit significantly higher atherogenic lipid profiles compared to those with Type 1 Diabetes Mellitus and healthy controls, with female diabetic patients showing slightly higher lipid values than males.
Answers are grounded in this paper and cite their sources.
May support lipid monitoring emphasis in type 2 diabetes; leaves open confirmation in larger prospective cohorts.
Objectives: Nearly 415 million world population is affected by diabetes mellitus (DM). Changes in lipid profile has been investigated to be associated with DM. Present study thus has conducted comprehensive analysis of lipid profile in DM. Methods: 50 cases each of Type 1 DM, Type 2 DM and control were included in present study which was conducted at Guru Gobindsinh Hospital, Jamnagar, Gujarat by Physiology department, M. P. Shah medical college. Apart from FBS and urine sugar, lipid profile (i.e. S. Cholesterol, S. Triglyceride, S. HDL, S. VLDL, S. LDL) was done using enzymatic colorimetric tests. Prior consent was taken from patients. Results: 72% cases in S. cholesterol, 74% cases in S. triglyceride, 72% cases in S. VLDL, 78% cases in S. LDL were found to be higher in Type 2 DM but with 30% of cases having low S. HDL level, it was inconclusive for association with Type 2 DM. However, majority of cases of Type 1 DM had all lipid profile levels within normal range. Conclusion: Results were comparable for both Type 1 and 2 DM with Mrunalini et al and Carolyn et al studies except for mean S. VLDL which was higher in present study compare to Carolyn et al study. To conclude Lipid profile was on higher side for Type 2 DM (except S. HDL which was inconclusive) but normal for Type 1 DM in majority of cases. In females
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Vala et al. (2018) conducted a case-control in Diabetes Mellitus (Type 1 and Type 2) (n=150). Diabetes Mellitus (Type 1 and Type 2) vs. Healthy controls was evaluated on Elevated lipid profile parameters (serum cholesterol, triglycerides, VLDL, LDL). Type 2 diabetes was associated with elevated serum cholesterol, triglycerides, VLDL, and LDL in over 70% of patients, whereas the majority of Type 1 diabetes patients maintained normal lipid profiles.
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