Key result
LV midwall fractional shortening remains stable with advancing age despite increasing endocardial fractional shortening.
Why the study?
Normal reference values and age-related physiological changes of left ventricular midwall fractional shortening (LV-FSmw) in Eastern populations were unknown despite its clinical importance in assessing LV systolic function.
Cross-Sectional (n=160)
No
p-value: p=0.88
May support midwall fractional shortening for age-independent systolic assessment; leaves open validation and outcome impact in broader populations.
BACKGROUND AND OBJECTIVES: Left ventricular (LV) midwall fractional shortening (FSmw) reflects systolic function more accurately than LV endocardial fractional shortening (eFS) in patients with increased LV wall thickness. Although the normal reference ranges of LV-FSmw have been suggested in Western population studies, its reference values and age-related physiological changes in Eastern populations remain unknown. SUBJECTS AND METHODS: Conventional echocardiographic parameters, LV-FSmw, and stress-corrected LV-FSmw were assessed in 160 healthy and clinically normal subjects with a mean age of 45 (range, 11-72 years; 104 males, 56 women), all of whom were confirmed to be free of disease, based on laboratory investigations, clinical and physical examination findings and computed tomographic coronary angiographic examinations. RESULTS: LV-FSmw was higher in women compared to men. However, the differences were without statistical significance (18.2±1.5% for male gender and 19.4±2.5% for female gender, p=0.07). In contrast to LV-eFS that progressively increased with age (p=0.001), LV-FSmw and stress-corrected LV-FSmw was not influenced by changes in age (p=0.88 and 0.29, respectively). The results remained unchanged when analyses were performed adjusting for gender. CONCLUSION: The results of this study provide normal reference values for LV-FSmw and stress-corrected LV-FSmw and their natural physiological changes with advancing age. These measures can be used as reference standards for research on LV systolic function in the setting of pressure or volume overload.
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Park et al. (2010) conducted a cross-sectional in Healthy individuals (n=160). Advancing age was evaluated on Change in left ventricular midwall fractional shortening (LV-FSmw) with advancing age (p=0.88). Left ventricular midwall fractional shortening remained stable regardless of advancing age (p=0.88) in healthy Korean subjects, in contrast to endocardial fractional shortening which progressively increased.
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