Nuclear bodies are dynamic structures that form at sites of specific activities associated with gene expression and genome maintenance. A paper in this issue (White et al. 2011. J. Cell Biol. doi: 10.1083/jcb.201012077) highlights key features of nuclear body biogenesis and suggests a unifying model in which formation of nuclear bodies is driven by nonrandom, biologically determined initial seeding events followed by stochastic self-assembly.
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Miroslav Dundr (2011) studied this question.
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