Key result
Severe renal dysfunction after out-of-hospital cardiac arrest is linked to ~57% lower 3-month survival.
Why the study?
Renal dysfunction is associated with increased cardiovascular mortality, but its impact on outcome of out-of-hospital cardiac arrest remains unclear.
Observational (n=5,112)
Yes
BACKGROUND: Renal dysfunction is associated with increased cardiovascular-related mortality, but its impact on outcome of out-of-hospital cardiac arrest (OHCA) remains unclear. We assessed whether post-OHCA outcome correlated with renal function early after OHCA. METHODS AND The adjusted OR for favorable neurological outcome also decreased with eGFR: 0.74 (95% CI: 0.52-1.06), 0.40 (95% CI: 0.25-0.64), and 0.48 (95% CI: 0.29-0.81), respectively. CONCLUSIONS: An independent and graded association was observed between decreased eGFR and 3-month survival and proportion of favorable neurological outcome in cardiogenic OHCA patients.
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Tamura et al. (2018) conducted an observational in Out-of-hospital cardiac arrest (n=5,112). Severely decreased eGFR (<30 mL/min/1.73 m2) vs. Normal eGFR (≥60 mL/min/1.73 m2) was evaluated on 3-month survival (OR 0.43, 95% CI 0.28-0.68, p=<0.001). Severely decreased renal function (eGFR <30 mL/min/1.73 m2) immediately after hospital arrival for cardiogenic out-of-hospital cardiac arrest was associated with significantly reduced odds of 3-month survival (OR 0.43) compared to normal renal function.
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