Physical and Chemical Characteristics and Structure of Carminomycin, a New Antitumor Antibiotic

Institute of New Antibiotics, Academy of Medical Sciences, Moscow, USSR In the course of our screening program we have isolated from the culture fo Actinomadura carminata carminomycin, a new anthracycline antibiotic which possessed strong antitumor activity in animal experiments. It is produced as a mixture of several active components: the more interesting ones are components 1, 2 and 3.Components 2 and 3 can be transformed by means of mild hydrolysis into carminomycin 1, which is obtained as a red crystalline hydrochloride C26H27O10N•HCl. The ultra-violet and visible spectra resemble that of daunomycin but are different.