On the Synthesis of Naphthoquinonyl Heterocyclic Amino Acids

All articles of this category L-Histidine, N α -cbz-L-histidine, L-tryptophan and L-proline react with 1,4-naphthoquinone or 2,3-dichloro-1,4-naphthoquinone to afford modified N -quinonyl amino acids. With free α -amino acids, the quinone moiety is attached to the α -amino group. With blocked α -amino acids the quinone moiety is attached to the heterocyclic nitrogen atom. 1,4-naphthoquinone - 2,3-dichloro-1,4-naphthoquinone - α -amino acids - N -quinonyl amino acids - Michael addition