Study on the Outcome of Treatment of Hyperuricemia with Febuxostat in Patients with Chronic Kidney Disease

Hyperuricemia, previously thought as a consequence of renal impairement, has been recently identified as an independent risk factor for the development of Chronic Kidney disease.This study was done to find out the effect of treatment of hyperuricemia in CKD patients.This observational study was conducted at Jubilee memorial hospital and Dr sm csi medical college, Trivandrum.The study population included 200 patients with CKD with hyperuricemia from the department of General medicine and department of Nephrology.Detailed history, anthropometry and clinical examination were recorded from all patients and serum uric acid levels and GFR before and 3 months after treatment were compared.Other study parameters were analysed within the CKD group.Treatment response of hyperuricemia with febuxostat among various stages of CKD was observed.Comparing prevalence hyperuricemia among different stages of CKD after 3month treatment with febuxostat, there was significant association between different stages of CKD and uric acid (p value=0.000).The present observational study suggests that febuxostat may slow the progression of mild-to-moderate CKD.Prevalence of hyperuricemia is significantly higher in chronic kidney diseases patients, especially stages 3 and 4. Uric acid level is significantly higher in overweight CKD subjects.