The Metabolism of the Catecholamines (Clinical Implications)

Clinical Staff Conference1 June 1962The Metabolism of the Catecholamines (Clinical Implications)Combined Clinical Staff Conference of the National Institutes of HealthROBERT A. COHEN, M.D., WILLIAM F. BRIDGERS, M.D., JULIUS AXELROD, PH.D., HANS WEIL-MALHERBE, M.D., ELWOOD H. LABROSSE, M.D., WILLIAM E. BUNNEY JR., M.D., PHILIPPE V. CARDON JR., M.D., SEYMOUR S. KETY, M.D.ROBERT A. COHEN, M.D., WILLIAM F. BRIDGERS, M.D., JULIUS AXELROD, PH.D., HANS WEIL-MALHERBE, M.D., ELWOOD H. LABROSSE, M.D., WILLIAM E. BUNNEY JR., M.D., PHILIPPE V. CARDON JR., M.D., SEYMOUR S. KETY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-6-960 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Robert A. Cohen: We wish to present today a review of some of our studies on the metabolism of the catecholamines. We shall begin with a discussion of some basic research on biosynthesis, and on the action of certain psychotropic drugs on the metabolism of the amines, and will then move on to clinical studies in normal controls and patients.We have selected this topic for several reasons. The catecholamines are of great importance to all of us; they are being widely studied throughout the National Institutes of Health, and we believe that it might be interesting to you...References1. ARMSTRONGMCMILLANSHAW MDAKN: 3-methoxy-4-hydroxy-d-mandelic acid, a urinary metabolite of norepinephrine. Biochim. Biophys. Acta 25: 422, 1957. CrossrefMedlineGoogle Scholar2. AXELROD J: O-methylation of epinephrine and other catechols in vitro and in vivo. Science 126: 400, 1957. CrossrefMedlineGoogle Scholar3. AXELRODKOPINMANN JIJJD: 3-methoxy-4-hydroxyphenylglycol sulfate, a new metabolite of epinephrine and norepinephrine. Biochim. Biophys. Acta 36: 576, 1959. CrossrefMedlineGoogle Scholar4. 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LABROSSE, M.D.; WILLIAM E. BUNNEYJR., M.D.; PHILIPPE V. CARDONJR., M.D.; SEYMOUR S. KETY, M.D.Affiliations: Bethesda, MarylandThis is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Maryland, by the National Institute of Mental Health, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.Requests for reprints should be addressed to Robert A. Cohen, M.D., National Institute of Mental Health, Bethesda 14, Maryland. 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PLASS, M.D.Electrophoretic separation of catecholamine metabolites and the quantification of norepinephrine-7H3 metabolites in manCurrent Concepts of DepressionSummaryCase 28-1963 1 June 1962Volume 56, Issue 6Page: 960-987KeywordsAttentionBiosynthesisCatecholaminesDrug metabolismDrug regulationDrugsExcretionMedical servicesPrevention, policy, and public healthPsychiatry and mental health ePublished: 1 December 2008 Issue Published: 1 June 1962 PDF downloadLoading ...