Key result
MI is linked to higher serum copper and lower zinc levels, but not manganese.
Why the study?
Previous reports of increased serum manganese concentrations after myocardial infarction were based on analyses of contaminated samples, necessitating re-investigation using accurate methods.
Observational
Does not support manganese monitoring post-MI; challenges prior contaminated reports and leaves biomarker role open.
Reportedly, serum manganese concentrations increase after myocardial infarction, closely correlated with increased serum aspartate aminotransferase activity. However, these conclusions are apparently based on analyses of contaminated samples. Serum manganese concentrations after myocardial infarction have been re-investigated by neutron activation analysis, and no significant increase could be demonstrated. Because serum copper and zinc could be determined simultaneously, analyses for these trace elements are also reported, which confirm the findings of others. After myocardial infarction a statistically significant (0.02 smaller than P smaller than 0.05) increase in serum copper and a statistically significant (0.001 smaller than P smaller than 0.01) decrease in serum zinc were observed.
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Versieck et al. (1975) conducted an observational in Myocardial Infarction. Myocardial infarction was evaluated on Serum manganese, copper, and zinc concentrations (p=0.02 < P < 0.05 (copper); 0.001 < P < 0.01 (zinc)). Myocardial infarction did not significantly increase serum manganese, but was associated with a significant increase in serum copper (P<0.05) and decrease in serum zinc (P<0.01).
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