Menopausal Symptoms and Quality of Life Among Breast Cancer Patients with Chemotherapy-induced Amenorrhea

Purpose: The aim of this study was to evaluate the severity of menopausal symptoms and their impact on the quality of life (QOL) in breast cancer patients with chemotherapy-induced amenorrhea.Methods: A cross-sectional survey design was used.Participants were 112 breast cancer patients with chemotherapy-induced amenorrhea.They completed the Menopause Rating Scale (MRS) and the Functional Assessment of Cancer Therapy-General (FACT-G).Data were analyzed using descriptive statistics, independent ttests, one-way ANOVA, Pearson' s correlation coefficients, and multiple regression with SPSS/WIN 23.0.Results: The prevalence of symptoms among the participants were as follows: sleep problems, 88.4%; physical and mental exhaustion, 80.4%; joint and muscular discomfort, 76.8%; and depression, 70.5%.Menopausal symptoms had a significant negative association with QOL.The results of the regression analysis showed that psychological and urogenital symptoms were statistically significant in explaining patients' QOL and accounted for 70% of the total variance.Conclusion: Menopausal symptoms appear to be a significant problem for premenopausal breast cancer patients.Assessment and control of menopausal symptoms played a large role in maintaining the quality of life in breast cancer patients.