Amlodipine-gold Nanoparticles as a New “Turn off-on’’ Sensor for the Sensitive Determination of Methimazole

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We present a new and sensitive fluorescent nanosensor for the direct determination of methimazole (MML) in human plasma samples. The strategy is based on fluorescence resonance energy transfer between amlodipine, an inexpensive pharmaceutical compound, as an energy donor and gold nanoparticles as an energy acceptor. The recovered fluorescence intensity in the presence of MML allows a direct and rapid quantitation of MML in human plasma samples with a detection limit of 0.15 ng/mL.