Seco-tremulane Sesquiterpenoids from the Cultures of the Medicinal Fungus Irpex lacteus HFG1102

Higher fungi are valuable and irreplaceable resources of natural product-derived lead compounds for drug research and development [ 1 ]. The fungus Irpex lacteus has been used as a medicinal fungus for decades in China for the treatment of inflammation, bacterial/fungal infection, and urinary retention [ 2 ]. The polysaccharide products of the submerged culture of I. lacteus have been developed and approved by SFDA as a clinically used drug for curing chronic glomerulonephritis [ 2 ]. However, although this fungus has been widely used as an industrial source to obtain polysaccharide products, its secondary metabolites remained unknown.