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January 1, 1985The Journal of AntibioticsOpen Access

Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (Heptelidic acid).

Akira Endo KENJI HASUM Kaoru Sakai Tomomi Kanbe

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Abstract

A sesquiterpene named koningic acid has been isolated from a strain of Trichoderma koningii as a potent inhibitor of ATP generation in the glycolytic pathway. From experiments with both cultured mouse carcinoma FM3A cells and isolated enzymes, it was shown that koningic acid is a specific inhibitor of glyceraldehyde 3-phosphate dehydrogenase that catalyzes the conversion of glyceraldehyde 3-phosphate to 3-phosphoglycerate.

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Cite This Study

Endo et al. (1985) studied this question.

synapsesocial.com/papers/6ac6e5ef1ec02ea6720f8719 https://doi.org/10.7164/antibiotics.38.920

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