Toxoplasmosis in Patients Receiving Immunosuppressive Therapy

Lethal, disseminated toxoplasmosis occurred in two patients, both of whom demonstrated severe central nervous system involvement. One patient, reported to have varicella zoster, was receiving immunosuppressive therapy following renal homotransplantation and is the third known patient to be reported with this infectious complication. The other patient was receiving steroids for severe marrow impairment due to a lymphoproliferative disorder, and had pathologic findings suggesting activation of latent disease.