Efficient Room‐Temperature One‐Pot Synthesis of 2‐Amino‐3‐alkyl(3‐aryl)quinazolin‐4( 3H )‐ones

Starting from anthranilates, the one‐pot successive addition of ethoxycarbonylisothiocyanate, alkyl‐ or arylamines, and the coupling reagent EDCI led to the clean, room‐temperature formation of carbamate‐protected 2‐amino‐3‐alkyl(3‐aryl)quinazolin‐4(3 H )‐ones in up to 93 % yield. This method provides a practical alternative to previously reported procedures for the synthesis of 2‐amino‐3‐substituted quinazolin‐4(3 H )‐ones.