Squamous cell carcinoma and basal cell epithelioma are not just two varieties of skin cancer; they belong to different classes of tumors, as was already pointed out by Lever in 1948. However, since 1948 it has become apparent that the essential difference is not point of origin or cause of tumor formation; rather, it is the differential biologic response of the adult skin to carcinogenic stimulation: development of independent epithelial cell strains in squamous cell carcinoma and adenocarcinoma, interdependent fibroepithelial proliferation in papillomas, benign adnexal tumors, and basal cell epithelioma.
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Hermann Pinkus (1965) studied this question.
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