Strategic use of both soft gold(I) and hard gold(III) catalysts provides azepanes from propargylic alcohols in one pot. Thus, propargylic alcohols in the presence of soft gold(I) catalyst (Ph 3 PAuNTf 2 ) undergo a Meyer–Schuster rearrangement to give α,β-unsaturated ketones, which in turn undergo a gold(III) (AuBr 3 )-catalyzed aza-Michael addition to afford azepanes bearing a carbonyl group.
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Morita et al. (2016) studied this question.