Key result
Hand-sewn ePTFE conduits achieve ~95% 7-year survival in pediatric right ventricular outflow tract reconstruction.
Why the study?
Adults with tetralogy of Fallot experience complications from long-term sequelae and treatment, requiring detailed imaging assessment.
Cohort (n=104)
No
May support conduit choice in pediatric RVOT reconstruction; leaves open need for comparative trials versus commercial options.
Tetralogy of Fallot (TOF) represents the most common form of cyanotic congenital heart disease, accounting for 6.8% of all congenital heart disease. As surgical techniques and medical management of patients with TOF have improved, most affected patients are reaching adulthood. Though surgical outcomes are favorable (<2% early mortality rate), adults with TOF may experience complications from the long-term sequelae of congenital heart disease and complications related to treatment. We describe common and uncommon findings in adults with TOF, including pulmonary insufficiency, central and peripheral pulmonary artery stenosis and aneurysms, in addition to graft and shunt-related complications. Pulmonary function abnormalities and lung parenchymal imaging findings will be detailed. The diagnostic value of computed tomography and magnetic resonance imaging in adults with complications of TOF will be illustrated.
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Gartner et al. (2010) conducted a cohort in Right heart diseases requiring right ventricular outflow tract reconstruction (n=104). hand-sewn ePTFE valved conduits was evaluated on Overall survival at 7 years (95% CI 88.6-97.9). Hand-sewn ePTFE valved conduits for right ventricular outflow tract reconstruction yielded a 95.1% 7-year survival rate and 75.3% freedom from conduit failure in pediatric patients.
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