Key result
DOAC-calibrated Heparin LRT assay aligns with DiXaI anti-Factor Xa assay for measuring DOAC concentrations.
Why the study?
Does the DOAC-calibrated Heparin LRT assay provide comparable measurements of apixaban, edoxaban, and rivaroxaban concentrations to the DiXaI reagent in patients with non-valvular atrial fibrillation?
Observational
Does the DOAC-calibrated Heparin LRT assay provide comparable measurements of apixaban, edoxaban, and rivaroxaban concentrations to the DiXaI reagent in patients with non-valvular atrial fibrillation?
The study evaluates a DOAC-calibrated Heparin LRT assay as a rapid alternative to a standard anti-Factor Xa assay for measuring apixaban, edoxaban, and rivaroxaban levels.
The data that support the findings of this study are openly available in Jin-Yeong Han at ORCID, reference number ORCID: 0000-0003-0280-2739. Figure S1: Passing–Bablok regression of DOAC concentrations measured with the DOAC-calibrated Heparin LRT reagent (Y axis) against the DiXaI reagent (X axis) for apixaban (A–C), edoxaban (D–F), and rivaroxaban (G–I) at trough, peak, and all sampling points combined. The solid line represents the regression line and the dotted line indicates the line of identity (Y = X). DOAC, direct oral anticoagulants; DiXaI, direct factor Xa inhibitor reagent; LRT, liquid reagent technology. Table S1: Baseline characteristics and reagent lower limits of quantification by DOAC. Both reagents were calibrated with drug-specific DOAC calibrators. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Woo et al. (2026) conducted an observational in Non-valvular atrial fibrillation. DOAC-calibrated Heparin LRT assay vs. Anti-Factor Xa Assay (DiXaI reagent) was evaluated. The DOAC-calibrated Heparin LRT assay was compared to the DiXaI anti-Factor Xa assay for measuring DOACs in non-valvular atrial fibrillation, with no quantitative results reported in the abstract.
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