Key result
Systemic infection in an infant triggers post-inflammatory true LV aneurysm complicated by fatal rupture.
Why the study?
Rupture of ventricular aneurysm is an unusual pathology in children with limited reported cases and clinical descriptions.
Case Report (n=1)
No
This case report presents the rare occurrence of an acquired post-inflammatory left ventricular aneurysm rupture leading to fatal cardiac tamponade in a preterm infant.
LV aneurysm rupture warrants consideration in deteriorating septic infants; leaves open whether prolonged infection causes true aneurysms in neonates.
Rupture of ventricular aneurysm is an unusual pathology in children. This case describes a preterm infant who had been in the hospital since birth due to necrotizing enterocolitis, which was complicated by narrowing of the ascending colon that required surgery. Throughout the entire period, the infant exhibited signs of infection, first caused by Staphylococcus haemolyticus and subsequently by Staphylococcus epidermidis . Several echocardiographic examinations did not reveal any significant changes; however, the final echocardiography revealed a structure connected to the left ventricular cavity. The infant experienced sudden cardiac arrest due to significant pericardial effusion. Despite continued resuscitation efforts, including emergency pericardiocentesis, the asystole recurred, further advanced life support measures were unsuccessful, and death was pronounced. Autopsy revealed a small outpouching on the anterior wall of the left ventricle, associated with thinning of the myocardium and a linear rupture with uneven edges. Histological examination showed that the aneurysm wall was composed of myocardium and connective tissue, exhibiting signs of inflammation, necrosis, and hemorrhage.
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Pereyaslov et al. (2026) conducted a case report in Left ventricular aneurysm rupture (n=1). Prolonged systemic Staphylococcus infection was evaluated on Death due to cardiac tamponade. Prolonged systemic infection in a 3-month-old infant led to a post-inflammatory true left ventricular aneurysm complicated by fatal rupture and cardiac tamponade.
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