Key result
Review outlines experimental strategies to identify cardiac microRNA targets for precision therapeutics.
Why the study?
Despite extensive research on microRNA responses in cardiac stress, much remains to be learned about their integrated actions on mRNAs and signaling pathways for therapeutic exploitation.
The short noncoding RNAs, known as microRNAs, are of undisputed importance in cellular signaling during differentiation and development, and during adaptive and maladaptive responses of adult tissues, including those that comprise the heart. Cardiac microRNAs are regulated by hemodynamic overload resulting from exercise or hypertension, in the response of surviving myocardium to myocardial infarction, and in response to environmental or systemic disruptions to homeostasis, such as those arising from diabetes. A large body of work has explored microRNA responses in both physiological and pathological contexts but there is still much to learn about their integrated actions on individual mRNAs and signaling pathways. This review will highlight key studies of microRNA regulation in cardiac stress and suggest possible approaches for more precise identification of microRNA targets, with a view to exploiting the resulting data for therapeutic purposes.
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Scot J. Matkovich (2014) conducted a review in Cardiac stress and hypertrophy. MicroRNA-based therapeutics and experimental techniques was evaluated. This review highlights principles and experimental practices for accurately identifying microRNA targets in cardiac stress to aid the development of precision microRNA-based therapeutics.
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