What/where is the active site? The determination of the metal ion content and makeup of the bacterial membrane protein methane monooxygenase (pMMO) has an enigmatic research history, despite protein X-ray structures. A new study appears to settle the issue; the dicopper center facilitates oxidation of methane to methanol. However, the unusual active-site environment leaves many questions for future investigations on the relevant copper-dioxygen chemistry and biochemistry.
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Himes et al. (2010) studied this question.
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