During the past several years the perspectives on headache have changed. This paper reviews the evolution of our understanding of headache and its mechanism, emphasizing the growing attention to neurobiological phenomena in headache pathogenesis. The continuum or transformation between migraine and tension headache is considered in detail, as are the importance of family history of headache, substance abuse, and sleep disturbances in the families of patients with headache. Treatments and clinical phenomena are reviewed.
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Joel R. Saper (1986) studied this question.
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