ClinGen and ClinVar – Enabling Genomics in Precision Medicine

Information.The mission of ClinGen is to provide authoritative, publicly available resources that define the clinical relevance of genes and variants for use in precision medicine and research (Rehm et al., 2015).ClinGen and ClinVar have a close partnership to improve sharing and access to genomic variant knowledge (ClinGen, 2018b).A major challenge for clinical laboratories has been to decide which genes have sufficient evidence to support their use in clinical care.