A correlative study using several techniques known to demonstrate reticuloendothelial (RE) cells was undertaken to determine whether the splenic sinus lining cells of the white rabbit should be classified with that group of cells. Like RE cells throughout the animal body, these cells can be demonstrated by silver precipitation techniques, that is, they are metalophilic. They show strong non‐specific esterase enzyme activity but only very slight acid phosphatase enzyme activity and sparingly phagocytize intravenous India ink (carbon), chlorazole black E, and saccharated oxide of iron. These results indicate these cells are reticuloendothelial in nature but are quite inactive when compared to RE cells of the red pulp cords.
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Michael J. Snodgrass (1968) studied this question.