AIM: To synthesize and functionalize platinum (core)-gold (shell) bimetallic nanoparticles (PtAuBNps) with chitosan and doxorubicin to display favorable pharmacokinetics, biodegradability, biological activity and safety in vitro. MATERIALS & METHODS: PtAuBNps and their drug nanocomposites were morphologically and physico-chemically characterized. Binding studies determined the efficiency and stability of the platform. In vitro release kinetics were evaluated under simulated environments, cytotoxicity profiles through MTT and Sulforodhamine B assays and apoptosis induction using the dual EtBr/AO staining. RESULTS & DISCUSSION: The results obtained indicate that functionalized PtAuBNps displayed favorable physio-chemical attributes, high binding capabilities, pH-triggered drug release through zero-order release kinetics, cell-specific cytotoxicity and good colloidal stability. CONCLUSION: The positive attributes of this novel delivery system bodes well for future in vivo studies.
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Maney et al. (2017) studied this question.
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