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The problem of antimicrobial resistance in microorganisms causing diarrheal diseases in both developed and developing countries continues to be alarming (6). Toxigenic Vibrio cholerae is the causative agent of the life-threatening disease cholera. Plasmid-encoded high-level resistance to ampicillin, kanamycin, streptomycin, sulfonamide, tetracycline, trimethoprim, and gentamicin has been demonstrated among strains of V. cholerae O1 isolated from Bangladesh, India, and Latin America (7, 9). Fluoroquinolones have excellent activity against all pathogenicVibrio species, and clinical trials have found norfloxacin to be effective for the treatment of cholera in adults and in children (2, 3).
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Mukhopadhyay et al. (1998) studied this question.
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