Lymphomatoid granulomatosis

The exact nature of lymphomatoid granulomatosis remains unclear. Whether it represents a viral infection, an autoimmune disorder (possibly induced by a virus), or primary malignant lymphoma, is still to be determined. The histopathology and clinical course allows classification of lymphomatoid granulomatosis as a distinct entity. Unfortunately, there is no consistently effective therapy for this condition and the usual course is rapidly downhill, though temporary remissions may be obtained. Since presentation of these patients with cutaneous lesions is not unusual, dermatologists must be alert to the possibility of an underlying systemic vasculitis in patients with atypical cutaneous ulceration, especially when no obvious cause is apparent.