Ferritin protein nanocages—the story

from the mineral with gated pores on the cytoplasmic surface of ferritin cages. Found in anaerobic and aerobic organisms, from archaea and bacteria to higher plants and animals, ferritins are required for life. They provide metabolic iron concentrates for protein cofactor synthesis, and antioxidant activity after stress. Current applications of ferritin nanocages include clinical measurements of trace amounts released into serum, nutritional sources of concentrated iron, nanomaterial templates, biological delivery of nanosensors, and nanocatalysts. Future applications can exploit the nucleation/ extrusion channels and other metal-protein sites in ferritins.