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Naturally occurring 17-deoxycorticosteroids (the term is used here to denote corticosteroids unsubstituted at position 17) comprise 21-hydroxypregnan-20-ones (I) and pregnane-20:21-diols (II).Oxidation with sodium bismuthate ruptures their 20-21 bond with the resultant formation of form- aldehyde from (I) and (II), of aetiocholanic acids I CO2H view of the distinctive chemical properties of aldehydes it was considered that this reaction sequence of proved analytical utility (Appleby, Gibson, Norymberski & Stubbs, 1955) might provide a means for the group determination of 17-deoxycorticosteroids by their conversion into 0-20 aldehydes and the measurement of the latter.
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Exley et al. (1961) studied this question.
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