For the purpose of confirming a useful therapy in chronic lower respiratory tract infections, we tried a long term (Mean: 16.8 months) chemotherapy with erythromycin (600-1200 mg/day) in 10 cases which included 3 cases with Pseudomonas infection. The disease of 10 cases was sinobronchial syndrome (SBS) with a large amount of purulent sputum, dyspnea on effort and hypoxemia. The principal organisms from transtracheal aspiration (TTA) were Haemophilusinfluenzae in 4 cases, Haemophilus influenzae and Streptococcus pneumoniae in 1 case, Streptococcus pneumoniae in 1 case, Haemophilus parainfluenzae in 1 case, Pseudonomas aeruginosa in 2 cases and Pseudonomas maltophilia in 1 case.The results of our therapy were as follows:1. Erythromycin waseffective in 9 cases exceptfor the 1 case with Haemophilus influenzae infection.2. The organisms from TTA or sputum were not eradicated in 9 cases except for the 1 case with Streptococcus pneumoniae infection.3. There were no observable side effects in any of the 10 cases.From these results, we consider that the long term chemotherapy with erythromycin is useful therapy in chronic lower respiratory tract infections including Pseudomonas aeruginosa infection.
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Sawaki et al. (1986) studied this question.