Key result
Ostial renal artery stenting linked to an ~18 mmHg reduction in systolic blood pressure.
Why the study?
The utility of endoprosthetic treatment for ostial renal artery stenosis in patients with coronary artery disease and hypertension was evaluated to assess effects on blood pressure, serum creatinine, and restenosis rate.
Observational (n=30)
Answers are grounded in this paper and cite their sources.
Renal artery stenting was associated with BP reduction in ostial stenosis with CAD; leaves open need for RCTs to confirm benefit versus medical therapy.
To test the utility of endoprosthetic treatment for ostial renal artery stenosis, and to examine blood pressure and its treatment, serum creatinine, and restenosis rate, 44 ostial renal stent placements were performed in 30 patients with concomitant coronary artery disease, arterial hypertension, and the indication for angiotensin converting enzyme (ACE) therapy. There was a marked decrease in systolic and diastolic blood pressure (163+/-30 to 145+/-17 and 93+/-18 to 83+/-10 mm Hg; P < 0.008) with a decrease in number of medication (3.2+/-0.9 to 2.8+/-1.0; P = 0.005). In 5 out of 8 patients not receiving an ACE inhibitor, this drug could be added. Serum creatinine changed from 1.46+/-0.7 mg/dl to 1.39+/-0.58 mg/dl (P = ns). Three patients showed restenosis (12.5%). Ostial stenting lowers blood pressure, decreases antihypertensive drugs and increases medication flexibility.
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Krämer et al. (1998) conducted an observational in Atherosclerotic renal artery stenosis with coronary artery disease and hypertension (n=30). Ostial renal artery stent placement was evaluated on Systolic and diastolic blood pressure (p=<0.008). Ostial renal artery stent placement significantly decreased systolic (from 163 to 145 mm Hg) and diastolic (from 93 to 83 mm Hg) blood pressure (P<0.008).
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