Non-Infectious Granulomatous Angiitis of the Nervous System Associated With Hodgkin's Disease

Neurological signs andsymptomsassociated with thegranulomatous formofHodgkin's disease area well recognized entity, though infrequent. Invariably these areduetooneoftwopathological processes, byfarthecommonest beingcompression ofthe central nervous systemfromwithout, mostfrequently byanepidural masswithin thespinal canal. An extremely rareoccurrence isdirect invasion of somepartofthenervous system byHodgkin's tissue. Therehavebeenmanyreviews ofthissubject (Ginsburg, 1927; Sparling, Adams,andParker, 1947; Hutchinson, Leonard, Maudsley, andYates, 1958). Winkelman andMoore(1941) emphasize thefact thattheinvolvement ofthecentral orperipheral nervous systems mayoccurasaninitial manifestationofHodgkin's disease. Inthefollowing case, theclinical picture from onset todeath wasthat ofaprogressive neurological disorder, late inthecourse ofwhichthediagnosis of Hodgkin's disease wasmadebylymphnodebiopsy. Atnecropsy noinvasion ofthenervous system by Hodgkin's granuloma wasfound. CLINICALHISTORY