Key result
A 12-week supervised hospital-based exercise program and a home-based pedometer program both resulted in significant but comparable declines in cardiorespiratory fitness during adjuvant breast cancer chemotherapy.
Why the study?
Cardiorespiratory fitness provides strong and independent prognostic information about cardiovascular and overall risk but is rarely used in clinical settings.
RCT (n=153)
Single-blind
1:1
Yes
Answers are grounded in this paper and cite their sources.
Exercise programs may not preserve cardiorespiratory fitness during chemotherapy; leaves open optimal strategies to protect this prognostic marker.
Cardiorespiratory fitness, as measured by a number of relatively simple and inexpensive clinical maneuvers, provides strong and independent prognostic information about the overall risk of illness and death, especially that from cardiovascular causes. This relationship extends to men, women, and adolescents. It is valid in apparently healthy persons; in patients with a broad range of maladies, including several types of cancer and cardiovascular disease; and in at-risk patients with diabetes mellitus, the metabolic syndrome, and hypertension.13 However, despite the profoundly important prognostic information provided by simple clinical assessments of fitness, they are rarely used in the clinical setting and . . .
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Kraus et al. (2005) conducted an RCT in Breast cancer undergoing adjuvant chemotherapy (n=153). Supervised hospital-based group exercise intervention vs. Instructed home-based individual pedometer intervention was evaluated on Change in cardiorespiratory fitness (VO2 peak) at 12 weeks. A 12-week supervised hospital-based exercise program and a home-based pedometer program both resulted in significant but comparable declines in cardiorespiratory fitness during adjuvant breast cancer chemotherapy.
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