The cell renewal rate of small intestinal mucosa was examined, based on the P32 incorporation into DNA, in the groups of acute and chronic riboflavin deficiency, acute anemia by venesection and chronic iron deficiency in rats and the following findings were obtained.1. In normal animals P32 incorporation into DNA in the epitheliar cells of the small intestinal mucosa arrived the maximal level about 48 hours after the injection, suggesting the complete replacement of the epitheliar cells of the mucosa in about 48 hours.2. In both acute and chronic riboflavin deficiencies, the renewal rate of the epitheliar cells of the small intestinal mucosa did not decrease. In chronic riboflavin deficiency it was rather significantly increased.3. The cell renewal rate was increased in acute anemia by venesection, whereas it was remarkably decreased in chronic iron deficiency.
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MIYAJI et al. (1966) studied this question.