An unfolding story: Simulations exceeding the microsecond timescale and the introduction of a co-solvent were used to characterize the pathways of the unfolding of a short DNA duplex. Two main pathways are detected involving different substrates. Once unfolding is reached the DNA adopts compact structures different from a random-coil distribution (see picture).
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Pérez et al. (2010) studied this question.
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