A nerve growth-promoting protein (NGF) has been identified in a number of vertebrate species, including the human fetus. This protein can be localized to the axial regions or the sympathetic chain directly, and wherever found is immunologically similar to NGF from mouse salivary gland. During development NGF appears concomitant with morphologic differentiation of the sympathetic chain and always in association with it. These studies further implicate the participation of the nerve growth-promoting protein in the regulation of growth of sympathetic ganglia.
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Winick et al. (1965) studied this question.
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