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To improve the accessibility of [18F]arylfluorides a method is presented using the decomposition of aromatic diazonium salts in the presence of [18F]fluoride. Several p-toluidyldiazonium salts have been synthesized and decomposed in the presence of fluoride. The most useful salt, p-toluidyldiazonium-2,4,6-tri-isopropylbenzenesulfonate, has been used to investigate several parameters influencing the fluorination. No-carrier-added labelling with [18F]fluoride gave a radiochemical yield of 39% [18F]p-fluorotoluene in a total synthesis time of 78 minutes.
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Knöchel et al. (1996) studied this question.
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