A comprehensive study of cancer survivor syndrome in adult patients with hematologic neoplasms

Purpose Cancer survivor syndrome (CSS) encompasses the multifaceted physical, psychological, and social challenges faced by individuals after completing active cancer treatment. This research aimed to estimate the frequency of CSS in adult cases had hematologic neoplasms, asses the risk factors and study the influence of CSS on quality of life in cases had hematologic neoplasms. Patients and methods An observational cross-sectional study was conducted in Clinical Hematology Unit of Internal Medicine Department-Assiut University Hospital, in the interval between January 2023 and January 2025. Results The prevalence of CSS was significantly higher in multiple myeloma (MM) cases (67.5%) in comparison with lymphoma patients (30%). MM patients exhibited poorer quality of life, higher distress, greater psychiatric morbidity, and more maladaptive coping. Associated factors of CSS included older age, lower education level, and shorter time since diagnosis in both groups, with female sex significant in lymphoma and diabetes mellitus significant in MM. Conclusion MM survivors experience a significantly greater burden of CSS than lymphoma survivors. Tailored survivorship care and early psychological intervention are crucial, particularly for higher-risk groups.