IgLON5 disease responsive to immunotherapy

A 45-year-old man was seen with a history of confusion and disorientation for 1 year, during which time he was unable to identify relatives. He was unable to cope at his work as a plasterer, noticed neck pain, dysphagia, and unexplained weight gain. His family reported that his sleep pattern had changed, describing his sleep as disturbed with episodes consistent with stridor, myoclonus (the video at [Neurology.org/nn][1]), and semipurposeful movements. Acknowledgment: The authors thank Edward Jackson and the staff in the Neurosciences Laboratories with the help processing and providing the immunofluorescence results. [1]: /lookup/doi/10.1212/NXI.0000000000000383