SLNs Based on Co-Processed Lipids for Topical Delivery of Terbinafine Hydrochloride

Onychomycosis is a fungal infection which is responsible for 50% of all nail disorders [1-3]. In 90% of the cases, onychomycosis is caused by dermatophytes (mainly Trichophyton rubrum), but can also be due to other fungi such as yeasts (mainly Candida albicans) or molds (mainly Scopulariopsis brevicaulis) [4]. Human nail, being composed of 80-90 layers of dead cells [5-7], prevents effective topical treatment of onychomycosis. Therefore, it is difficult to achieve therapeutic antimicrobial drug concentration in the nail. High incidences of onychomycosis and problems associated with its therapy have renewed the interest of formulation scientists to work towards alternative formulation approaches [8].