Key result
No significant cross-sectional associations were observed between primary T-cell subsets (CD4+CD28-CD57+ and Th1 T-cells) and endothelial function measured by flow-mediated dilation.
Why the study?
The role of peripheral T cell subsets in endothelial function and their associations in a multi-ethnic community-based cohort were not well characterized.
Are peripheral circulating T-cell subsets associated with endothelial function in a multi-ethnic cohort free from cardiovascular disease?
Cross-Sectional (n=968)
Yes
Are peripheral circulating T-cell subsets associated with endothelial function in a multi-ethnic cohort free from cardiovascular disease?
Answers are grounded in this paper and cite their sources.
While primary targeted pro-inflammatory T-cell subsets did not correlate with endothelial function, broader differences in pan CD4+ and CD8+ subsets warrant further mechanistic investigation in cardiovascular risk.
We investigated whether peripheral T cells were associated with endothelial function in a multi-ethnic cohort. No significant associations were observed between Th1 or CD4+CD28-CD57+ T cells with endothelial function in the primarily analysis. A higher value of pan CD4+ T cells was associated with lower endothelial function, while a higher value of pan CD8+ T cells was associated with higher endothelial function in the secondary analysis. This study provides epidemiological data linking pan T cells to measures of endothelial function.
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DeConne et al. (2025) conducted a cross-sectional in Subclinical Cardiovascular Disease Risk (n=968). Peripheral circulating T-cell subsets (CD4+CD28-CD57+ and Th1 T-cells) was evaluated on Endothelial function assessed by absolute and percent change in flow-mediated dilation (FMD) (p=>0.05). No significant cross-sectional associations were observed between primary T-cell subsets (CD4+CD28-CD57+ and Th1 T-cells) and endothelial function measured by flow-mediated dilation.
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