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January 1, 1984The Journal of AntibioticsOpen Access

A new antitumor antibiotic, kazusamycin.

IWAO UMEZAWA Kanki Komiyama Hirofumi Oka Kenji Okada Shigeru Tomisaka Tetsuji Miyano Satomi Takano

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Abstract

A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity against HeLa cells in vitro. The chemical and physico-chemical properties of kazusamycin suggest that the molecular formula of this antibiotic is C33H48O7 (MW 556).

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UMEZAWA et al. (1984) studied this question.

synapsesocial.com/papers/6acd81910f8b281fe200bf91 https://doi.org/10.7164/antibiotics.37.706

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