Qsofa Score for Diagnostics of Sepsis. Results of the Russian Multi-Center Trial of Rises

Subjects and methods. The mult i-c enter, prospective, and observational trial was conducted. The following data were analyzed in the patients admitted to intensive care wards: number of q SOFA scores, the presence of SIRS criteria, levels of lactate, procalcitonin, C-r eactive protein in blood, the presence of sepsis according to Sepsi s-3 criteria. The value of q SOFA scores, SIRS criteria, and biomarkers for sepsis diagnostics was assessed by means of RO C -a nalysis. Results. The following areas under RO C -c urves were defined during diagnostics of sepsis in the patients in intensive care wards: q SOFA – 0.679 (95% CI 0.646–0.712); SIRS – 0.714 (95% CI 0.682–0.745), p = 0.099; when q SOFA exceeding 1 score: procalcitonin – 0.788 (95% CI 0.689–0.867), C-r eactive protein – 0.787 (95% CI 0.688–0.866), p = 0.970. Conclusion. q SOFA score is compatible with SIRS criteria for diagnostics of sepsis among the patients in intensive care wards. q SOFA score is highly sensitive, but it is of low specificity for sepsis diagnostics. Should there be at least 1 score of q SOFA , it is recommended to test levels of procalcitonin or C-r eactive protein in order to increase the specificity of this score for diagnostics of sepsis.