Hemoglobin Necker Enfants-Malades was fortuitously found during a systematic measurement of Hb AIc in a diabetic patient. It displays an electrophoretic pattern similar to that of Hb A but can be distinguished by isoelectricfocusing or cation exchange chromatography. Functional studies reveal no abnormal features.
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Wajcman et al. (1980) studied this question.
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