Nucleophilic Vinylic Substitution (SNV) of Activated Alkoxymethylene Derivatives with 6‐Aminoquinoxaline

Treatment of 6‐aminoquinoxaline with β,β‐diactivated alkoxymethylene derivatives gave the corresponding N‐(quinoxalin‐6‐yl)enamines. A variant of the SNV reaction mechanism was proposed for substitution of the alkoxymethylene compounds, on the basis of the structures of the precursor enol ether and the vinylic substitution product and on computations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)