Answers are grounded in this paper and cite their sources.
Twelve kinds of 2-pyrazolin-5-one derivatives, substituted in the 1, 3, or 4 position were synthesized and relationship between their structure and antitubercular action was examined. With the exception of 3-methyl derivatives, compounds substituted in the 1, 3, or 4 position were found to have generally weaker antibacterial action. The action of the 3-methyl derivative against human-type tubercle bacilli, H37RV strain, was equal to that of 2-pyrazolin-5-one and was effective up to a concentration of 3 γ/cc.
No takes yet. Share an insight, caveat, or question.
Toshiyasu Ishimaru (1957) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: