Solubility Enhancement of Diflunisal by Solid Dispersion Techniques

The study was carried out with a view to enhance dissolution rate of poorly water soluble drug by preparing tablets of solid dispersion of Diflunisal. The solid dispersion was prepared by using carriers like Crosspovidone, PEG and Urea. The solid dispersion was prepared by Physical mixture, Fusion, Kneading and Solvent evaporation methods using different ratio of Diflunisal and carrier. The optimized solid dispersion batch F8 and F9 were incorporated into tablets for faster release of Diflunisal. In-vitro dissolution rate of both batches of Diflunisal from solid dispersion was found to be 99.49 % and 98.90 % drug release after 2 hr compared to 46.27% release shown by pure drug after 2 hr.