The solubility of protected peptides as well as the coupling rate was quantitatively examined in highly polar solvents. Symmetrical anhydrides in dimethyl sulfoxide (DMSO) containing N,N-dimethylformamide (DMF) or DMF solution of lithium chloride and diethyl phosphorocyanidate with triethylamine in DMSO–DMF were proved to be efficient coupling reagents for solid phase synthesis of hardly soluble peptides.
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Morii et al. (1989) studied this question.
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