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October 11, 2026Clinical & Experimental Allergy

PROTEGO Study Protocol: A Cluster Randomised Crossover Trial of Vernix Caseosa Retention for Primary Prevention of Atopic Dermatitis

Arturo Borzutzky Carolina Cabalín Juan Pablo Fraga Jorge Fabres Alberto Toso Marcelo Farías M Cossio María José Escalante Paula Fajuri Maite Rojas-McKenzie Magdalena Sande Rosario Willatt Carolina Barrientos Robert Boyle

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Abstract

Summary PROTEGO is a Chilean cluster‐randomised crossover trial of vernix caseosa retention to prevent atopic dermatitis. 1383 mother‐infant dyads will be enrolled and followed for atopic dermatitis until 12 months.

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Cite This Study

Borzutzky et al. (2026) studied this question.

synapsesocial.com/papers/6acdc9b6ff4480e723d7a6f6 https://doi.org/10.1111/cea.70449

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1PEBBLES study protocol: a randomised controlled trial to prevent atopic dermatitis, food allergy and sensitisation in infants with a family history of allergic disease using a skin barrier improvement strategyClinical Trial · 2019 · 64 citations
2EFFECTIVENESS OF ENHANCING THE SKIN BARRIER SINCE EARLY INFANCY TO PREVENT INFANTILE ATOPIC DERMATITIS AND FOOD SENSITIZATION: A RANDOMIZED CONTROLLED TRIAL2024
3Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT2024 · 8 citations
4Evaluation of the efficacy of PREVENIR (PREVention ENvIronment Reproduction) platforms on urinary markers of chemical exposure in pregnant women: protocol for an unblinded randomised clinical trial (PREVENIR-G)2025
5Protocol design for the ACTIVATE clinical trial: Exposure to vaginal microbiome in cesarean-delivered infants at high risk for allergiesHuman Clinical Trial · 2025 · 3 citations

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Evaluation of antenatal prebiotic intake in infants at risk of atopy: the double-blind PREGRALL randomized clinical trial2025
PROTECT-Preterm: Emulating target trials of dynamic probiotic strategies for necrotising enterocolitis, late-onset sepsis, and mortality in very preterm infants: a study protocol2026
Healthy Diet Intervention for Treating Atopic Dermatitis: A Pilot Randomised Controlled Trial2026

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